Phenylpropanoids and polyketides
Medchemexpress LLC 4'-Hydroxyflavone | 4143-63-9 | MFCD00017687 | 97.0% | 238.24 g/mol | C15H10O3 | 10 MG
4'-Hydroxyflavone is a flavone-class small molecule used in research as an aldose reductase inhibitor. It is supplied as a high-purity research reagent for biochemical assays and is commonly used in enzyme inhibition studies, structure-activity relationship (SAR) investigations, and small-molecule screening.
- High purity (97.0%)
- Molecular formula C15H10O3
- Molecular weight 238.24 g/mol
- CAS number 4143-63-9
- Reported aldose reductase IC50 12 μM
- Suitable for enzyme inhibition assays and SAR studies
Medchemexpress LLC 5-Hydroxyflavone | 491-78-1 | 99.8% | 238.24 | 25 MG
5-Hydroxyflavone is a flavonoid ligand that shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells.
- Flavonoid ligand
- No cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells
- Solid, light yellow to yellow appearance
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 2 years, -20°C for 1 year
Apexbio Technology LLC Troxerutin 7085-55-4 5g
Troxerutin (CAS 7085-55-4) is a bioactive small molecule known to exhibit protective effects against gamma radiation (GR)-induced DNA damage It promotes DNA repair mechanisms thereby reducing radiation-related single- and double-strand breaks Experimentally Troxerutin (1 mM) decreased GR-triggered micronucleus formation in human lymphocytes by approximately 41% In mouse models intraperitoneal administration before or after irradiation (up to 175 mg/kg) minimized micronucleus frequency in reticulocytes and mitigated DNA strand breaks in leukocytes and bone marrow cells with dosage-dependent results Its properties make Troxerutin relevant for radiation biology research particularly in genomic stability and radioprotection studies
TARGETMOL CHEMICALS INC 4-Hydroxyflavone 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 4'-Hydroxyflavone is a flavonoid compound isolated from the roots of Scutellaria baicalensis with anti-inflammatory activity. Purity 99.42%
Medchemexpress LLC Chrysin-7-O-glucuronide | 35775-49-6 | 1 ML
Chrysin-7-O-glucuronide is a flavonoid extracted from *Scutellaria baicalensis*, possessing antioxidant activity. It inhibits α-glucosidase and α-amylase, suppresses NF-κB signaling activity, scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. This compound is suitable for research related to type 2 diabetes and severe acute pancreatitis-induced intestinal barrier injury.
- Inhibits alpha-glucosidase and alpha-amylase
- Suppresses NF-κB signaling activity
- Scavenges free radicals
- Acts as a tight junction protector
- Mitigates intestinal mucosal barrier injury
- Restores ZO-1 expression and tight junction structure
- Ameliorates SAP-induced intestinal mucosal barrier injury in rats
Cayman Chemical ChrysIn 7-GlucuronIde 25mg
A flavonoid glucuronide with diverse biological activities and an active metabolite of chrysin; inhibits α-glucosidase, α-amylase, and neuraminidase (IC50s = 612, 980, and 428 UG/ml, respectively); inhibits OATP1A2, OATP1B1, OATP1B3, OATP2B1, BCRP, and MRP2 (IC50s = 24.1, 4.4, 14.3, 0.3, 19.8, and 11.2 µM, respectively)
Sigma Aldrich Fine Chemicals Biosciences Naringin >=90%, from citrus fruit | 10236-47-2 | MFCD00148888 | 100G
Naringin >=90%, from citrus fruit | Purity: >=90% | Mol Wt: 580.53 | 10236-47-2 | MFCD00148888 | 100G
Cayman Chemical SalvIa plebeIa npItrIn 5mg
A flavonoid glycoside with diverse biological activities; protects lard from thermal oxidation at 0.02 and 0.04%; inhibits carrageenin-induced edema and yeast-induced fever in rats; decreases serum levels of triglycerides and LDL, as well as increases serum HDL levels, in a rat model of high-fat diet-induced atherosclerosis at 20 and 50 mg/kg
Selleck Chemical LLC AMG 487
AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8 0 nM and 8 2 nM respectively
Medchemexpress LLC Psb-sb-487 | 1399049-81-0 | 98.0% | 408.53 g/mol | C26H32O4 | 50MG
PSB-SB-487 is a small-molecule research compound that functions as a potent GPR55 antagonist and a CB2 receptor agonist. It is supplied as a white to off-white solid for laboratory use and is intended for research use only. The compound has CAS number 1399049-81-0 and a molecular weight of 408.53 g/mol.
- Potent GPR55 antagonist and CB2 agonist.
- High purity (approximately 98.0%).
- Molecular formula C26H32O4; molecular weight 408.53 g/mol.
- Supplied as a white to off-white solid.
- Soluble in DMSO at high concentration (100 mg/mL; ultrasonic recommended).
- Recommended storage conditions for powder and solutions to maintain stability.
- For research use only; not for human or diagnostic use.
Apexbio Technology LLC AST 487 630124-46-8 10mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Crescent Chemical Co Inc NAPHTHOL-AS-MX-PHOSPHATE
Naphthol-AS-MX-phosphate research grade Selective substrate of alkaline phosphatase. Suitable for dye coupling. Fast Blue RR (1). Fast Red TR-salt (cat. no. 21317) (2). Size - 250MG Storage Conditions - -15 °C TO -25 °C Catalog Number - 30002.01 CAS No.
Apexbio Technology LLC (±)-AMG 487 10mg
racemic Baclofen -AMG 487 is a small-molecule antagonist targeting the chemokine receptor CXCR3 It is designed to inhibit ligand-induced CXCR3-mediated immune cell migration thereby modulating lymphocyte recruitment to inflammatory and metastatic sites racemic Baclofen -AMG 487 exerts its biological activity primarily through selective inhibition of CXCR3-mediated cell migration In in vitro studies racemic Baclofen -AMG 487 demonstrates inhibition of ligand-induced CXCR3-dependent cell movement Based on these pharmacological properties racemic Baclofen -AMG 487 holds research potential in inflammation and oncology studies